2021/07/15 Drawing blood to early detect Alzheimer’s disease

Traditionally, Alzheimer’s disease (AZ) is diagnosed with behavioral and cognitive performance. An international research team leading by the HKUST has developed a simple blood test to detect Alzheimer’s disease. The researchers developed a composite biomarker panel that consisted of 19 AZ-related proteins. They then generated a AZ classification score by using this panel together with other factors (e.g., age, sex). This classification score was found to be able to differentiate individuals with AZ from healthy control with an accuracy level up to 96%. This score was also able to delineate the stages of the disease.
 
Article Website:
 
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12369
 
Journal Reference:

Yuanbing Jiang, Xiaopu Zhou, Fanny C. Ip, Philip Chan, Yu Chen, Nicole C.H. Lai, Kit Cheung, Ronnie M.N. Lo, Estella P.S. Tong, Bonnie W.Y. Wong, Andrew L.T. Chan, Vincent C.T. Mok, Timothy C.Y.

Kwok, Kin Y. Mok, John Hardy, Henrik Zetterberg, Amy K.Y. Fu, Nancy Y. Ip. Large‐scale plasma proteomic profiling identifies a high‐performance biomarker panel for Alzheimer's disease screening and staging. Alzheimer's & Dementia, 2021; DOI: 10.1002/alz.12369